Coxibs and NSAIDs

Review of the cardiovascular safety of COXIBs compared to NSAIDS

There is no doubt that NSAIDs and COXIBS are the mainstay for managing pain and inflammation in arthritis. Overall, at therapeutically equivalent doses, both NSAIDs and COXIBs provide equivalent analgesic and anti-inflammatory efficacy. However, the gastrointestinal risk associated with NSAIDs is considerable. More recently, the cardiovascular risk associated with NSAIDs and COXIBs has become a...

NSAIDs and Coxibs in Chemoprevention Non-steroidal Anti-inflammatory Drugs and Coxibs In Chemoprevention: A Commentary Based Primarily on Animal Studies

Cutaneous hypersensitivity to multiple NSAIDs: never take tolerance to selective COX-2 inhibitors (COXIBs) for granted!

Nonsteroidal anti-inflammatory drugs are one of the most frequent causes of immediate drug-induced skin hypersensitivity reactions worldwide (1). While a proportion of patients show reactivity to single, specific drugs, many others are intolerant to multiple NSAIDs; about one half of multiple reactors suffer from chronic spontaneous urticaria, while in the remaining no underlying factor can be ...

Coxibs and the endothelium.

In this issue of the Journal, Title et al. (1) present the results of the much-awaited randomized double-blind evaluation of rofecoxib on endothelial function in patients with coronary artery disease (CAD). From a cardiovascular standpoint, cyclooxygenase-2 (COX-2) inhibitors have been the topic of much discussion, debate, and trepidation (2–5). Mechanistically, the concern about the use of the...

Coxibs and Heart Disease

Since their approval in 1998, the popularity of selective cyclooxygenase-2 (COX2) inhibitors has swung from a domination of drug sales to serious disputes about their cardiovascular safety. Despite the numerous studies on COX2 inhibitors that have emerged, drawing conclusions about their cardiovascular safety has been complicated by conflicting results, underpowered clinical trials, and the lac...